I've had a 220 and 2 250's.
The current owner of my 220 lurks on here occasionally and I have driven it as recently as last summer. TBH there is very little difference. That particular car has always felt very strong in terms of performance and the 220 has a bit less lag than the 250 so it feels as fast as my 250 did if not more so.
That 220 is a very early one with optional LSD (and Fuchs at one time) but was before ABS. That is a nice spec IMO, although when I bought it I had actually gone to see a 2.5 Lux and it was a spur of the moment, lucky purchase [&:]
Why then do I have a 250 now? Apart from the 250 being a newer car (which doesn't bother me in the slightest) they have a few advantages: LSD is standard, most have leather, drive shafts are bigger, brakes are bigger, they tend to be available in a wider range of colours, etc. Basically I wanted a metallic one with leather and I wanted a basis for tuning so the bigger components and LSD swung it for me.
It is worth bearing in mind that the Guru kits are from the US and there were hardly any 250T's sold there, whereas there were huge numbers of 220's, so the kit is designed to perform with the 220 base car. My old one is being Guru'd right now with high 130k miles.
My current car had the head off for a blown gasket at 149k and the bottom end looked good. Even the turbo was only rebuilt because it was a "what's another £400?" rebuild and it seemed like a good time to do it. Leakdown tests after repair were between 3% and 6%. 3 weeks later when I holed the sump and it came apart completely the bottom end was found to be very good - good enough to go again if I didn't intend to keep the car. Properly maintained then, with regular changes of good quality oil and if they are allowed to warm up and cool down properly they last very well and should be OK with a mild tune suc as a Guru kit.